What to Do About Twitching | Masterjohn Q&A Files #314

B6 status matters for glutamate-GABA balance relevant to twitching.

Trial magnesium (~400 mg) for twitching; magnesium clears calcium in muscle, acts as NMDA receptor off-switch.

Supplement molybdenum to control sulfite, which enhances glutamate toxicity, especially with high animal protein intake.

Check postprandial urine pH; it should fall between 6.4 and 6.8. Below 5s suggests acidity; above 7 suggests alkalinity as a possible twitching factor.

Use bicarbonate to modulate urine pH upward if too acidic.

Use acidic foods/beverages to lower urine pH if too alkaline.

Chloride is among electrolytes to consider trialing for twitching.

Trial sodium supplementation around 400 mg to test effect on twitching.

Trial potassium supplementation (~400 mg) to test effect on twitching.

Calcium may be trialed as an electrolyte for twitching given its role in vesicle release and muscle contraction.

Observe whether things that increase metabolism worsen twitching to identify hypermetabolic causes.

Measure blood levels of B vitamins if acute interventions don't resolve twitching.

If acute factors don't resolve twitching, measure B vitamin levels or trial a B complex.