Metformin
Every recorded take from the experts Cited tracks — each with the exact quote, source, and timestamp.
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Organic (prompted) In a protocol
Bryan includes metformin in his daily protocol as one of the advanced longevity drugs.
“or metformin or carbos
TD▶ 1:11:58CaveatsPrescription drugCertaintypersonal onlyoffhand mention -
In a protocol
AMPK activator; Sinclair takes 800 mg at night with dinner, skips on workout days; lowers risk of cancer, heart disease, Alzheimer's in diabetics.
“I take 800 milligrams at night
LW▶ 1:06:00Dosage800 mg at night with dinner; skip on days before exerciseCaveatsCan cause lactic acidosis (rare, severe); upset stomach; may slightly reduce exercise gains; requires prescription in USCertaintypersonal onlypersonal use -
Alternative
Metformin is preferred as first-line therapy for gestational diabetes due to extensive ongoing safety data.
“we would typically turn to something like metformin as a first-line therapy there
TP▶ 1:07:40Certaintyexplicitrecommendation -
In a protocol
Metformin used in the TRIM trial (with growth hormone and DHEA) contributed to ~2.5 years biological age reversal over 12 months.
“included metformin, growth hormone and dhea
LW▶ 52:50DosageAs used in TRIM trialCaveatsPart of an experimental protocol.Certaintyhedgedrecommendation -
Organic (prompted)
Attia moved metformin from 'promising' to 'fuzzy' — Bannister 2014 epidemiology had methodological flaws, Keyes 2022 showed opposite, and metformin failed ITP alone.
“today I would place it in the fuzzy category
TP▶ 17:20CaveatsFailed in ITP alone; Keyes 2022 showed mortality increase in diabetics on metforminCertaintyhedgedmild caution