Startled?! Try Glycine!
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What Chris Masterjohn recommended
In transcript order-
Try supplemental glycine as a first-line approach for an exaggerated startle reflex, since glycine neurotransmission overwhelmingly governs the motor startle response.
“if you have an exaggerated startle reflex, glycine should be the first thing to look at
DosageTherapeutic window roughly 3–20+ grams/day; 60 g shown safe (used in schizophrenia)CaveatsNot medical advice; consult doctor; avoid if you have a glycine cleavage defect; may raise lactate in respiratory chain disorders; rare hypoglycemia anecdotesCertaintyhedgedrecommendation -
Topical benzoyl peroxide acne creams can deplete glycine via hippurate formation and sap glutathione synthesis.
“if you put benzoyl peroxide on a pimple, you absorb 5% ... going to conjugate the glycine
Certaintyexplicitmild caution -
Diets centered on skinless boneless muscle meat skew methionine high and glycine low.
“this ridiculous almost century-long fad diet of eating skinless boneless chicken breast leads to glycine deficiency
Certaintyexplicitmild caution -
Eat skin and bones, not just muscle meat, to maintain glycine intake and balance methionine.
“no longer eating nose to tail is the reason that most of us run low on glycine
Certaintyexplicitrecommendation -
Alternative
Collagen supplementation provides about 3 g glycine per 10 g and can be used to raise glycine status.
“Roughly 3 grams out of every 10 grams of gelatin or collagen is glycine
Dosage~3 g glycine per 10 g collagenCaveatsMay raise oxalate more than isolated glycineCertaintyexplicitrecommendation -
Alternative
Gelatin can be used to raise glycine intake; roughly 3 g of glycine per 10 g of gelatin.
“supplement with glycine, gelatin, collagen, or bone broth
Dosage15 g gelatin (~5 g glycine) before exercise for joint collagen synthesisCaveatsMay raise oxalate more than isolated glycineCertaintyexplicitrecommendation -
Alternative
Bone broth provides glycine; about 3 g of glycine per cup of well-gelled bone broth.
“3 grams of glycine can be obtained from each cup of a well-gel bone broth
Dosage~3 g glycine per cup well-gelled bone brothCaveatsMore likely than isolated glycine to raise oxalateCertaintyexplicitrecommendation -
Use a Nova Biomedical Lactate Plus meter to measure waking morning lactate to detect respiratory chain stress when supplementing glycine.
“measuring your waking morning lactate with Innova Biomedical Lactate Plus
DosageMeasure waking morning lactate; rise after glycine indicates respiratory chain stressCertaintyexplicitrecommendation -
Run the Genova Methylation Panel as related testing for methylation/glycine status.
“the Genova Methylation Panel
Certaintyexplicitoffhand mention -
Chris Masterjohn's Comprehensive Nutritional Screening protocol is recommended for related testing.
“my Comprehensive Nutritional Screening
Certaintyexplicitoffhand mention -
Chris Masterjohn's Comprehensive Screening for Energy Metabolism is suggested as related testing.
“Comprehensive Screening for Energy Metabolism
Certaintyexplicitoffhand mention