Nicotinamide mononucleotide (NMN)
Every recorded take from the experts Cited tracks — each with the exact quote, source, and timestamp.
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Huberman uses NMN for morning energy but explicitly states he has never called NAD/NMN a longevity drug.
“I do augment NAD using NMN. It gives me more morning energy
HL▶ 1:40:56CaveatsNot claimed as longevity drug; also causes thicker nails and faster hair growth (unintended)Certaintypersonal onlypersonal use -
Organic (prompted) In a protocol
Bryan trialed NMN for 90 days and showed it raised his intracellular NAD to age-18 levels; he says NMN and NR work about equally well.
“I did 90 days on NMN... both were basically effective
TD▶ 1:13:20DosageTitrate dose to measured intracellular NAD levelsCaveatsMeasure to confirmCertaintyhedgedrecommendation -
NMN combined with exercise gives the best benefit; not a substitute for exercise but synergistic with it.
“when you give NMN and you exercise, you get the best benefit
LW▶ 43:50CaveatsNot a substitute for exercise.Certaintyhedgedpersonal use -
In a protocol Alternative
NAD precursor; Sinclair takes 1 g every morning; raises NAD ~2-fold and shows insulin sensitivity benefits in humans.
“I take one gram of NMN every morning
LW▶ 1:05:00Dosage1 g in the morning; can go up to 2 gCaveatsCaution in people predisposed to pancreatic cancer (Nacarelli 2019 mouse study); consult physicianCertaintypersonal onlypersonal use -
Alternative
Same skepticism applies to NMN — raises NAD but no shown phenotypic benefit in healthy aging.
TP▶ 1:07:00Certaintyexplicitmild caution