TRIM Trial Protocol
Greg Fahey's experimental epigenetic age reversal protocol combining three agents over 12 months, shown to reverse blood biological age by ~2.5 years.
Assembled by Cited from David Sinclair's recorded recommendations across multiple sources. It is not an ordered program and was not created or endorsed by them — it's our grouping of what they've said on the record.
Components
3-
In a protocol
Growth hormone used in Fahy's TRIM trial to rebuild tissues as part of an age reversal protocol.
“growth hormone will rebuild tissues
LW▶ 52:50DosageAs used in TRIM trialCaveatsExperimental protocol; needs medical supervision.Certaintyhedgedoffhand mentionGrowth hormone rebuilds tissues and signals body that times are good. -
In a protocol
Metformin used in the TRIM trial (with growth hormone and DHEA) contributed to ~2.5 years biological age reversal over 12 months.
“included metformin, growth hormone and dhea
LW▶ 52:50DosageAs used in TRIM trialCaveatsPart of an experimental protocol.CertaintyhedgedrecommendationMetformin counteracts glucose spikes from growth hormone. -
In a protocol
DHEA used alongside metformin and growth hormone in TRIM trial to counteract glucose spikes and diabetes risk.
“the metformin and the DHEA prevented glucose spikes
LW▶ 52:50DosageAs used in TRIM trialCaveatsExperimental protocol.Certaintyhedgedoffhand mentionDHEA also counteracts glucose spikes and diabetes risk.
How this protocol has evolved
Fahey has reportedly repeated this treatment multiple times in patients, with some reports of 5-10 years of blood biological age reversal.