SIRI Inflammation Assessment
Use the CBC with differential (already in most people's records) to calculate the Systemic Inflammatory Response Index (SIRI = monocytes × neutrophils / lymphocytes) as a cheap, accessible first-pass measure of chronic inflammation and immune aging.
Assembled by Cited from Jeffrey Bland's recorded recommendations across multiple sources. It is not an ordered program and was not created or endorsed by them — it's our grouping of what they've said on the record.
Components
2-
In a protocol
Use the standard CBC with differential — already in most people's records — to calculate inflammatory status.
“complete blood count with differential, CBC with differential
TR▶ 43:00Dosage~$6 test; available in existing medical recordsCaveatsBroad-brush first-pass tool; more specific testing existsCertaintyexplicitstrong endorsementObtain CBC with differential — $6 test usually already in medical records -
In a protocol
Calculate SIRI = (monocytes × neutrophils) / lymphocytes from CBC; >1 indicates chronic inflammation, <1 is normal.
“systemic inflammatory response index. S I, R I
TR▶ 45:00DosageSIRI = monocytes × neutrophils ÷ lymphocytes; >1 = chronic inflammation; track every ~90-120 daysCaveatsRough broad-brush tool, not definitiveCertaintyexplicitstrong endorsementCalculate SIRI from CBC values; track ~every 90-120 days as immune cells turn over