#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance
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What Peter Attia recommended
In transcript order-
Attia discusses 2000 IU vitamin D as used in DO-HEALTH but notes it failed to move any aging clocks, possibly due to dose being too low.
“2000 IU of vitamin D is not going to do much
Dosage2000 IU/day (as tested in DO-HEALTH)CaveatsDose may have been insufficient; 30% of participants had baseline <20 ng/dL.Certaintyhedgedoffhand mention -
Attia notes that in the DO-HEALTH trial, modest omega-3 supplementation (1 g/day with 330 mg EPA, 660 mg DHA from marine algae) was the most consistent intervention to slightly slow several epigenetic aging clocks over 3 years.
“the most consistent finding was that something about omega-3 supplementation moved the needle
Dosage1 g/day (330 mg EPA + 660 mg DHA) for 3 years, as used in DO-HEALTHCaveatsEffect size was small (~3 months of reduced aging over 3 years); unclear clinical significance.Certaintyhedgedoffhand mention -
Attia cautions against using consumer aging clock tests for individual decision-making, saying current evidence doesn't show that changing the clock changes meaningful health outcomes.
“it's not clear that these numbers actually give consumers any actionable information
CaveatsClocks may still be useful as research tools and could evolve clinically.Certaintyexplicitmild caution