Why Should Postprandial Glucose Be Kept Under 140 mg/dL? | Masterjohn Q&A Files #323
Auto-extracted preview. These recommendations were transcribed and classified from the episode audio. Timestamps link to the source; classifications are not yet editorially verified.
What Chris Masterjohn recommended
In transcript order-
Organic (prompted)
Keep postprandial blood glucose under 140 mg/dL because that's roughly the threshold where the polyol pathway activates, taxing NADPH and reducing glutathione and vitamin C recycling.
“when glucose spikes over 140 mg per deciliter, this is generally around the threshold associated with activation of the polyol pathway
DosageKeep postprandial glucose < 140 mg/dL; average glucose response < 120 mg/dLCaveatsGoing over 140 occasionally is not destructive, just suboptimal; don't catastrophize CGM spikesCertaintyexplicitrecommendation -
Repeatedly consume a glycemic load to adapt; peak glucose drops with each exposure. Health concern is inability to adapt, not single spikes.
“you rapidly adapt over time to glucose
DosageRepeated trials with same glycemic load (e.g., 40 g glucose) separated by a few days; observe adaptation over ~3+ trialsCaveatsDon't conclude anything from a single glucose reading without testing repeatabilityCertaintypersonal onlypersonal use -
Don't use CGM readings above 140 to eliminate foods from your diet; avoidance can worsen glucose intolerance by losing adaptation.
“they run from the plasma glucose and they progressively get more and more glucose intolerant
CaveatsSingle spikes over 140 are not dangerous; repeated inability to adapt is the real concernCertaintyhedgedmild caution